Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.
Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
The combination of clonidine and chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).
Do not use this medication if you are unable to urinate.
Before using this medication, tell your doctor if you are allergic to sulfa drugs, or if you have liver disease, kidney disease, asthma, allergies, gout, lupus, or diabetes.
Avoid drinking alcohol, which can increase some of the side effects of clonidine and chlorthalidone. Do not stop using this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, anxiety, severe high blood pressure, or life-threatening symptoms. You will need to use less and less before you stop the medication completely.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to the side effects of clonidine and chlorthalidone.
This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Do not use this medication if you are allergic to clonidine or chlorthalidone, or if you are unable to urinate.
Before using clonidine and chlorthalidone, tell your doctor if you are allergic to any drugs, or if you have:
if you have an allergy to sulfa drugs.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take clonidine and chlorthalidone.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Clonidine and chlorthalidone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.
To be sure this medication is helping your condition, your blood pressure will need to be checked often. Do not miss any scheduled appointments.
Your blood and urine may both be tested if you have been vomiting or are dehydrated.
Chlorthalidone can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.
Keep using clonidine and chlorthalidone as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.
Avoid drinking alcohol, which can increase some of the side effects of clonidine and chlorthalidone.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Clonidine and chlorthalidone can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
impotence or loss of interest in sex.
Tell your doctor about all other medications you use, especially:
an antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).
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